Association of maternal thyroid function during early pregnancy with offspring IQ and brain morphology in childhood: a population-based prospective cohort study
Tim Korevaar, Ryan Muetzel, Marco Medici, Layal Chaker, Vincent Jaddoe, Yolanda de Rijke, Eric Steegers, Theo Visser, Tonya White, Henning Tiemeier, Robin Peeters
Weinig en veel schildklierhormoon in zwangerschap risico voor IQ kind
Thyroid hormone is involved in the regulation of early brain development. Since the fetal thyroid gland is not fully functional until week 18–20 of pregnancy, neuronal migration and other crucial early stages of intrauterine brain development largely depend on the supply of maternal thyroid hormone. Current clinical practice mostly focuses on preventing the negative consequences of low thyroid hormone concentrations, but data from animal studies have shown that both low and high concentrations of thyroid hormone have negative effects on offspring brain development. We aimed to investigate the association of maternal thyroid function with child intelligence quotient (IQ) and brain morphology.